KILLFILE 2.0

I think you need to enclose the name of each of the users in quotes. Otherwise I think JS will think those are variable references to other objects, you want strings here:

// instead of this below
var fules = [/karl malone/,/fule2/];
// do it like this
var fules = ["/karl malone/","/fule2/"];

i'm embarrassed that i can't get this working. it's my second time in two months

KARLFILE 2.0

i haven't checked this, because it's 5am here, but my initial thoughts are that quotes are unnecessary (the example works without quotes) but capital letters are - Karl doesn't match karl.

additionally, that looks like an old version of the script, the current one (2018) is here (i think the link on boards page is old and this thread is tl;dr)

https://github.com/acdean/kilxor/blob/master/kilxor.user.js

the images suggest a different problem, perhaps (uri not listed?), but try this first