'price no indicator of worth'

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that link does not disprove what i say

this backs up what i'm saying tho

http://www.pharmtech.com/role-reverse-engineering-development-generic-formulations

Determining the original drug's excipient content and other formulation optimization steps can be facilitated using reverse engineering, which is the decoding of an innovator product's formulation parameters. Such parameters include the quantitative composition of the innovator product, the solid-state characterization of the active pharmaceutical ingredient (API), and the manufacturing process.

Although some information about an innovator drug product's API and excipient components can be found in common sources such as product information brochures, Physician's Desk Reference, or FDA's Web site ( http://www.fda.gov/), one can be more confident about the generic product's performance by developing a formula that is as qualitatively and quantitatively similar to the reference listed drug (RLD) as possible. Under US law, quantitative information about the excipients in oral dosage forms is not required to be revealed. In this context, reverse engineering of the innovator product's formulation is a scientifically sound and cost-effective strategy for accelerating generic product development. From a practical perspective, the chances of developing a bioequivalent product can be significantly increased by extending the concept of generic product sameness to formulation sameness with the RLD. Generic product sameness is defined in terms of pharmaceutical equivalence and bioequivalence. Formulation sameness with the RLD is defined in terms of equivalence of qualitative and quantitative formulas, solid state characteristics, and manufacturing process to the RLD (see Sidebar, "Generics terminology").

F♯ A♯ (∞), Thursday, 16 March 2017 18:47 (seven years ago) link

i believe generic drugs are reversed engineered because branded have secret proprietary formulas/ingredients

― F♯ A♯ (∞), Thursday, March 16, 2017 10:21 AM (one hour ago) Bookmark Flag Post Permalink

but some branded drugs are like literally acetaminophen or like an anti-histamine that was developed in the 60s. i feel like surely any drug company can confidently make these now.

if it were some newer drug recently developed then i guess if they were reversed engineered i could see the difference

Islamic State of Mind (jim in vancouver), Thursday, 16 March 2017 18:51 (seven years ago) link

i actually wasn't referring to the quality

but i agree with

went through all this with various drs and drugs when a family member had a terminal disease

generic brands have less research/study done (if at all) unless they've been around for ages

F♯ A♯ (∞), Thursday, 16 March 2017 19:02 (seven years ago) link

like we would be told such and such medication has been shown to do this and that

then they'd recommend the generic one, but the generic one wasn't always included in the research/study

F♯ A♯ (∞), Thursday, 16 March 2017 19:05 (seven years ago) link

Gigs in large venues.

Ongar Is An Energy (Tom D.), Friday, 17 March 2017 09:02 (seven years ago) link

I was prescribed generic codeine painkillers by my GP, but found that that they made me vomit, whereas the Panadol codeine painkiller doesn't. So my guess is that part of the Panadol 'secret formula' is a stomach settler that the generics don't bother with.

Bernie Lugg (Ward Fowler), Friday, 17 March 2017 09:48 (seven years ago) link

Healthcare generally though

SFTGFOP (El Tomboto), Friday, 17 March 2017 11:01 (seven years ago) link

hotel rooms in medium-sized or small cities.

ready meals or pre-prepared food.

restaurants generally.

wine to an extent.

Bein' Sean Bean (LocalGarda), Friday, 17 March 2017 11:03 (seven years ago) link

hotel rooms in medium-sized or small cities

this is a good one. feels like pot luck, more or less. exceptional cheap ones (with owners who care about what they do) and laughable expensive ones (boilerplate breakfasts, tiny hot rooms with no view etc). Sometimes in the same city.

Fizzles, Friday, 17 March 2017 12:12 (seven years ago) link

a $200 bottle of tom ford perfume doesn't smell any better than a $30 of guerlain

clouds, Friday, 17 March 2017 12:40 (seven years ago) link

this is a good one. feels like pot luck, more or less. exceptional cheap ones (with owners who care about what they do) and laughable expensive ones (boilerplate breakfasts, tiny hot rooms with no view etc). Sometimes in the same city.

yeah it is madness. i am staying in brighton this weekend and there were places for like £200 that were just standard daintily renovated townhouses. two hundred pounds. in the end i got a place for about £85. i've paid a bit for the odd hotel over the years but for £200 i'd expect a spa, swimming pool, incredible service, a nice bar, and maybe to be in a major city.

Bein' Sean Bean (LocalGarda), Friday, 17 March 2017 13:29 (seven years ago) link

George Osborn's wages.

Hey Bob (Scik Mouthy), Friday, 17 March 2017 13:29 (seven years ago) link

Markets are irrational, so pretty much everything.

Matt DC, Friday, 17 March 2017 14:34 (seven years ago) link


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